- Product Details
Keywords
- Cetilistat
- 282526-98-1
- C25H39NO3
Quick Details
- ProName: Cetilistat
- CasNo: 282526-98-1
- Molecular Formula: C25H39NO3
- Appearance: white powder
- Application: pharmaceutical active ingredient
- DeliveryTime: within 3-7 day
- PackAge: As required
- Port: shanghai or other
- ProductionCapacity: 5 Metric Ton/Month
- Purity: 99(%)
- Storage: keep in dry and cool condition
- Transportation: by sea or by air
- LimitNum: 1 Kilogram
Superiority
Changzhou Xuanming Chemical Co., Ltd. is dedicated to the technology development, manufacturing, import and export chemicals, which are specialized in pharmaceutical intermediates, pesticide intermediate, industry of fine chemicals and custom synthesis. Now, we enjoy good reputation among customers and take favorable market share in domestic and at abroad.
Changzhou Xuanming Chemical CO., LTD is located in Northern Jiangshu Industry Park, we have modern manufacture bases and some laboratories, which can supply the key intermediate for your projects, and short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard. We have been abided by “treat technology as first, quality as basis, customers as God, and be honest and sincere”. It is our final aim to provide environmental and high technological products and meet customers’ requirements according to keep effors on developing new chemical fields.
Changzhou Xuanming Chemical CO., LTD promises to help you with heart and soul.
Details
Cetilistat Basic information |
Product Name: | Cetilistat |
Synonyms: | 4H-3,1-Benzoxazin-4-one,2-(hexadecyloxy)-6-Methyl-;Xinli orlistat;cetilistat;Cetilistat(Alt-962);Cetilstat;Cetilistat (282526-98-1);2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one;2-(Hexadecycloxy)-6-methyl-4H-3,1-benzoxazin-4-one |
CAS: | 282526-98-1 |
MF: | C25H39NO3 |
MW: | 401.58 |
EINECS: | 1308068-626-2 |
Product Categories: | Cetilistat;Other series;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;-;Pharmaceuticals;API |
Mol File: | 282526-98-1.mol |
Cetilistat Chemical Properties |
Melting point | 72.0 to 76.0 °C |
density | 1.02 |
InChIKey | MVCQKIKWYUURMU-UHFFFAOYSA-N |
CAS DataBase Reference | 282526-98-1(CAS DataBase Reference) |
Safety Information |
Cetilistat Usage And Synthesis |
Description | Cetilistat (also known as ATL-962) was approved in September 2013 by the Japanese Ministry of Health, Labor and Welfare for the treatment of obesity, limited to patients with both type 2 diabetes mellitus (T2DM) and dyslipidemia, and with a body mass index (BMI)25 kg/m2 in spite of dietary treatment and/or exercise therapy. As with orlistat, cetilistat works via inhibition of pancreatic lipases in the gut to inhibit fat absorption and thereby reduce caloric uptake from diet. The medicinal chemistry program has not been described in the scientific literature, but the patent describing cetilistat also describes the synthesis of analogs with varied aryl substituents and lipophilic tails. The synthesis of cetilistat involves condensation of a hexadecylcarbonochloridate with 2-amino-5-methylbenzoic acid; other analogs were synthesized by varying the carbonochloridate and 2-aminobenzoic acid components. Cetilistat is a potent inhibitor of human and rat pancreatic lipase with IC50s of 15 and 136 nM, respectively, with little inhibition of trypsin or chymotrypsin. |
Chemical Properties | Off-white Cryst |
Originator | Alizyme PLC (United Kingdom) |
Uses | A novel pancreatic lipase inhibitor for the treatment of obesity in both diabetic and non-diabetic patients. |
Brand name | Oblean |
Cetilistat Preparation Products And Raw materials |