China (Mainland)
Azelastine hydrochloride CAS NO.79307-93-0
- Min.Order: 10 Gram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Product Details
Keywords
- Azelastine hydrochloride
- 79307-93-0
- C22H25Cl2N3O
Quick Details
- ProName: Azelastine hydrochloride
- CasNo: 79307-93-0
- Molecular Formula: C22H25Cl2N3O
- Appearance: white crystalline powder
- Application: Pharmaceutical Intermediates
- DeliveryTime: 2-3day
- PackAge: As required
- Port: shanghai or other
- ProductionCapacity: 5 Metric Ton/Month
- Purity: 99（%）
- Storage: Keep in a cool & dry place
- Transportation: by sea or by air
- LimitNum: 10 Gram
Superiority
Changzhou Xuanming Chemical Co., Ltd. is dedicated to the technology development, manufacturing, import and export chemicals, which are specialized in pharmaceutical intermediates, pesticide intermediate, industry of fine chemicals and custom synthesis. Now, we enjoy good reputation among customers and take favorable market share in domestic and at abroad.
Changzhou Xuanming Chemical CO., LTD is located in Northern Jiangshu Industry Park, we have modern manufacture bases and some laboratories, which can supply the key intermediate for your projects, and short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard. We have been abided by “treat technology as first, quality as basis, customers as God, and be honest and sincere”. It is our final aim to provide environmental and high technological products and meet customers’ requirements according to keep effors on developing new chemical fields.
Changzhou Xuanming Chemical CO., LTD promises to help you with heart and soul.
Details
| Azelastine hydrochloride Basic information |
| Product Name: | Azelastine hydrochloride |
| Synonyms: | 4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride;Allergodil;Astelin;Optilast;Rhinolast;Aselastine;1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride;Acelastine hydrochloride |
| CAS: | 79307-93-0 |
| MF: | C22H25Cl2N3O |
| MW: | 418.36 |
| EINECS: | 620-469-0 |
| Product Categories: | Antihistaminic;Intermediates & Fine Chemicals;-;Pharmaceuticals;Histamine receptor;Astelin |
| Mol File: | 79307-93-0.mol |
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| Azelastine hydrochloride Chemical Properties |
| Melting point | 225--2290C |
| storage temp. | -20°C Freezer |
| solubility | DMSO: >10mg/mL |
| form | powder |
| color | white to off-white |
| Merck | 14,906 |
| Stability: | Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 79307-93-0(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RTECS | TH9203900 |
| HS Code | 2933992600 |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 36.5, 35.5, 26.9, 30.3 i.v.; 56.4, 42.8, 43.2, 46.6 i.p.; 63.0, 54.2, 66.5, 59.6 s.c.; 124, 139, 310, 417 orally (Zechel) |
| Azelastine hydrochloride Usage And Synthesis |
| Description | Azelastine hydrochloride is an orally effective antihistamine useful in the treatment of asthma and nasal allergy. It appears to inhibit release of histamine, in addition to antagonizing its action. |
| Chemical Properties | White or almost white, crystalline powder. |
| Originator | Asta-Werke(Degussa) (W. Germany) |
| Uses | Orally active H1-hystamine receptor antagonist. Antihistaminic |
| Definition | ChEBI: The hydrochloride salt of azelastine. |
| Brand name | Astelin (Medpointe); Optivar (Medpointe);AZEPTIN. |
| General Description |
(±)-4-[(4-chlorophenyl)methyl]-2-(hexahydro-l-methyl-1H-azepin-4-yl)-l-(2H)-phthalazinone monohydrochloride (Optivar), is a whitecrystalline powder that is sparingly soluble in water,methanol, and propylene glycol and slightly soluble inethanol, octanol, and glycerine. The commercial preparationis available as a 0.05% sterile ophthalmic solution fortopical administration to the eyes. Each milliliter of azelastinesolution contains 0.5-mg azelastine hydrochlorideequivalent to 0.457 mg of azelastine base, the preservativebenzalkonium chloride (0.125 mg), and inactive ingredientsincluding disodium edetate dihydrate, hydroxypropylmethylcellulose,sorbitol solution, sodium hydroxide, andwater for injection. The solution has a pH of approximately5.0 to 6.5 and an osmolality of approximately 271to 312 mOsm/L. The recommended dose of azelastine solution is 1 dropinstilled into each affected eye twice a day. This drugproduct is for ocular administration only and not for injectionor oral use. Absorption of azelastine following ocularadministration is relatively low (less than 1 ng/rnL).Absorbed drug undergoes extensive oxidative N-demethylationby CYP, and the parent drug and metabolite are eliminatedprimarily in the feces. The most frequently reportedadverse reactions are transient eye burning or stinging,headaches, and bitter taste. Azelastine solution should beused with caution during pregnancy or while nursing, becauseits safety has not been studied under these circumstances. |
| Azelastine hydrochloride Preparation Products And Raw materials |
