China (Mainland)
Clevidipine butyrate CAS NO.167221-71-8
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Product Details
Keywords
- Clevidipine butyrate
- 167221-71-8
- C21H23Cl2NO6
Quick Details
- ProName: Clevidipine butyrate
- CasNo: 167221-71-8
- Molecular Formula: C21H23Cl2NO6
- Appearance: white to off-white powder
- Application: PharmaIntermediate
- DeliveryTime: within 3-7 day
- PackAge: As required
- Port: shanghai or other
- ProductionCapacity: 5 Metric Ton/Month
- Purity: 99%
- Storage: keep in dry and cool condition
- Transportation: by sea or by air
- LimitNum: 1 Kilogram
Superiority
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Details
| Clevidipine butyrate Basic information |
| Product Name: | Clevidipine butyrate |
| Synonyms: | Clevidipine, Cleviprex;Methyl (1-oxobutoxy)methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dime thyl-3,5-pyridinedicarboxylate;4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-Pyridinedicarboxylic acid methyl (1-oxobutoxy)methyl ester;Clevidipine butyrate;Cleviprex;3,5-Pyridinedicarboxylicacid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-methyl5-[(1-oxobutoxy)methyl] ester;Clevidipine Butyrate/Cleviprex;4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-diMethyl-3,5-pyridinedicarboxylic Acid 3-Methyl 5-[(1-Oxobutoxy)Methyl] Ester |
| CAS: | 167221-71-8 |
| MF: | C21H23Cl2NO6 |
| MW: | 456.32 |
| EINECS: | 682-702-2 |
| Product Categories: | -;Aromatics;Pharmaceuticals;Clevidipine Butyrate impurity;Heterocycles;Intermediates & Fine Chemicals;Cardiovascular APIs |
| Mol File: | 167221-71-8.mol |
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| Clevidipine butyrate Chemical Properties |
| Melting point | 128-130°C |
| density | 1.289 |
| Fp | 280℃ |
| storage temp. | Refrigerator |
| Safety Information |
| Safety Statements | 24/25 |
| HS Code | 29339900 |
| Clevidipine butyrate Usage And Synthesis |
| Description |
Clevidipine is an ultra-short-acting vasodilator of the dihydropyridine (DHP) class of CCB. It is indicated as an intravenous treatment for the acute management of hypertension when oral therapy is not feasible or not desirable. Clevidipine is the second intravenous CCB to be marketed behind nicardipine for this indication. Both agents are primarily used for urgent treatment of hypertension in cardiac surgical setting, intensive care units, and emergency departments. Other intravenous agents currently on the market for this indication include sodium nitroprusside, nitroglycerin, fenoldopam, hydralazine, esmolol, and labetalol. Clevidipine is a potent, arterial-specific, vasodilator with very little or no effect on the myocardial contractility and venous capacitance. It has a rapid onset and offset of action and a very short plasma half-life, which allows for titration of the drug to achieve precise BP control. clevidipine is exclusively metabolized in the blood and the tissues. It does not undergo any renal or hepatic metabolism and does not accumulate in the body. Clevidipine is a blocker of L-type calcium channels, which mediate the influx of calcium during depolarization in arterial smooth muscle. |
| Chemical Properties | White to Off-White Solid |
| Originator | AstraZeneca (United Kingdom) |
| Uses | Clevidipine butyrate is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure。 |
| Uses | Calcium channel blocker, used as an oral antihypertensive. |
| Uses | Seroquel XR |
| Uses | A calcium channel protein inhibitor and blocker |
| Brand name | Clevelox (The Medicines Company). |
| Side effects | Clevidipine is contraindicated in patients with severe aortic stenosis, defective lipid metabolism, and allergies to eggs, egg products, soybeans, or soy products. The chemical synthesis of clevidipine entails the esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester with chloromethyl butyrate by the action of potassium bicarbonate in refluxing acetonitrile. |
| Chemical Synthesis | The chemical synthesis of clevidipine entails the esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester with chloromethyl butyrate by the action of potassium bicarbonate in refluxing acetonitrile. The DHP-monoester starting material is obtained in two steps through condensation of methyl 2,3-dichlorobenzylidine acetoacetate and 2-cyanoethyl ester of 2-amino-2-propenoic acid to the DHP diester, followed by base catalyzed cleavage of the cyanoethyl group. Clevidipine is practically insoluble in water and is formulated in an oil-inwater emulsion. |
