China (Mainland)
- Product Details
Keywords
- Ketoprofen
- 22071-15-4
- C16H14O3
Quick Details
- ProName: Ketoprofen
- CasNo: 22071-15-4
- Molecular Formula: C16H14O3
- Appearance: White Crystalline Solid
- Application: pharma intermediate
- DeliveryTime: 2-3day
- PackAge: 25KG/Cardboard bucket or as required
- Port: shanghai or other
- ProductionCapacity: 5 Metric Ton/Month
- Purity: 98（%）
- Storage: Stored in shaded, cool and dry places
- Transportation: by air or by sea
- LimitNum: 1 Metric Ton
Superiority
| Ketoprofen Basic information |
| Product Name: | Ketoprofen |
| Synonyms: | ORUDIS;ORUVAIL;RARECHEM AL BO 1306;19583 RP;19583rp;2-(3-benzoylphenyl)-propionicaci;2-(m-Benzoylphenyl)propionic acid;2-(m-benzoylphenyl)propionicacid |
| CAS: | 22071-15-4 |
| MF: | C16H14O3 |
| MW: | 254.28 |
| EINECS: | 244-759-8 |
| Product Categories: | Pharmaceutical ingredients;-;Pharmaceutical;Active Pharmaceutical Ingredients;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Lipid signaling;Pharmaceutical raw material;API;ACTRON;Other APIs;Analgesics |
| Mol File: | 22071-15-4.mol |
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| Ketoprofen Chemical Properties |
| Melting point | 93-96°C |
| Boiling point | 357.5°C (rough estimate) |
| density | 1.1565 (rough estimate) |
| refractive index | 1.5600 (estimate) |
| storage temp. | 0-6°C |
| solubility | Slightly soluble in chloroform and methanol. |
| pka | pKa 5.94(MeOH/H2O) (Uncertain) |
| form | solid |
| Merck | 14,5305 |
| InChIKey | DKYWVDODHFEZIM-UHFFFAOYSA-N |
| CAS DataBase Reference | 22071-15-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Ketoprofen(22071-15-4) |
| EPA Substance Registry System | Benzeneacetic acid, 3-benzoyl-.alpha.-methyl-(22071-15-4) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 25-36/37/38-23/24/25 |
| Safety Statements | 26-45-36/37/39 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| RTECS | UE7570000 |
| TSCA | Yes |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29183000 |
| Toxicity | LD50 orally in rats: 101 mg/kg (Ueno) |
| Ketoprofen Usage And Synthesis |
| Used in Particular Diseases |
Acute Gouty Arthritis: Dosage and Frequency: 75 mg four times a day |
| Chemical Properties | White Crystalline Solid |
| Uses | Natural Vitamin B12. analog |
| Uses | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. |
| Uses | Anti-inflammatory; analgesic |
| Definition | ChEBI: An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2. |
| Indications | Ketoprofen (Orudis) is indicated for use in rheumatoid and osteoarthritis, for mild to moderate pain, and in dysmenorrhea. The most frequently reported side effects are GI (dyspepsia, nausea, abdominal pain, diarrhea, constipation, and flatulence) and CNS related (headache, excitation). Edema and increased blood urea nitrogen have also been noted in more than 3% of patients. Ketoprofen can cause fluid retention and increases in plasma creatinine, particularly in the elderly and in patients taking diuretics. |
| Brand name | Actron (Bayer); Orudis (Wyeth); Oruvail (Wyeth). |
| General Description | Ketoprofen (Orudis, Rhodis) and suprofen (Profenal) areclosely related to fenoprofen in their structures, properties,and indications. Even though ketoprofen has been approvedfor OTC use (Orudis KT, Actron), its GI side effects aresimilar to indomethacin, and therefore its useshould be closely monitored, especially in patients with GIor renal problems. |
| Contact allergens | Ketoprofen is an anti-inflammatory drug, used both topically and systemically. It is above all a photoaller- gen, responsible for photoallergic or photo-worsened contact dermatitis, with sun-induced, progressive, severe, and durable reactions. Recurrent photosensitiv- ity is possible for many years. Photosensitivities are expected to thiophene-phenylketone derivatives such as tiaprofenic acid and suprofen, to ketoprofen esters such as piketoprofen, and to benzophenone derivatives (see above) such as fenofibrate and benzophenone-3. Concomitant photosensitivities without clinical rel- evance have been observed to fenticlor, tetrachloro- salicylanilide, triclosan, tribromsalan, and bithionol. |
| Veterinary Drugs and Treatments | Ketoprofen is labeled for use in horses for the alleviation of inflammation and pain associated with musculoskeletal disorders. Like flunixin (and other NSAIDs), ketoprofen potentially has many other uses in a variety of species and conditions. There are approved dosage forms for dogs and cats in Europe and Canada. Some consider ketoprofen to be the NSAID of choice for use short-term for analgesia in cats. |
Details
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