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Home > Products >  Cetilistat

Cetilistat CAS NO.282526-98-1

  • Min.Order: 1 Kilogram
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  • Product Details

Keywords

  • Cetilistat
  • 282526-98-1
  • C25H39NO3

Quick Details

  • ProName: Cetilistat
  • CasNo: 282526-98-1
  • Molecular Formula: C25H39NO3
  • Appearance: white powder
  • Application: pharmaceutical active ingredient
  • DeliveryTime: within 3-7 day
  • PackAge: As required
  • Port: shanghai or other
  • ProductionCapacity: 5 Metric Ton/Month
  • Purity: 99(%)
  • Storage: keep in dry and cool condition
  • Transportation: by sea or by air
  • LimitNum: 1 Kilogram

Superiority

Changzhou Xuanming Chemical Co., Ltd. is dedicated to the technology development, manufacturing, import and export chemicals, which are specialized in pharmaceutical intermediates, pesticide intermediate, industry of fine chemicals and custom synthesis. Now, we enjoy good reputation among customers and take favorable market share in domestic and at abroad.

Changzhou Xuanming Chemical CO., LTD is located in Northern Jiangshu Industry Park, we have modern manufacture bases and some laboratories, which can supply the key intermediate for your projects, and short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard. We have been abided by “treat technology as first, quality as basis, customers as God, and be honest and sincere”. It is our final aim to provide environmental and high technological products and meet customers’ requirements according to keep effors on developing new chemical fields.

Changzhou Xuanming Chemical CO., LTD promises to help you with heart and soul.

Details

Cetilistat Basic information
Product Name: Cetilistat
Synonyms: 4H-3,1-Benzoxazin-4-one,2-(hexadecyloxy)-6-Methyl-;Xinli orlistat;cetilistat;Cetilistat(Alt-962);Cetilstat;Cetilistat (282526-98-1);2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one;2-(Hexadecycloxy)-6-methyl-4H-3,1-benzoxazin-4-one
CAS: 282526-98-1
MF: C25H39NO3
MW: 401.58
EINECS: 1308068-626-2
Product Categories: Cetilistat;Other series;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;-;Pharmaceuticals;API
Mol File: 282526-98-1.mol
Cetilistat Structure
 
Cetilistat Chemical Properties
Melting point  72.0 to 76.0 °C
density  1.02
InChIKey MVCQKIKWYUURMU-UHFFFAOYSA-N
CAS DataBase Reference 282526-98-1(CAS DataBase Reference)
 
Safety Information
MSDS Information
 
 
Cetilistat Usage And Synthesis
Description Cetilistat (also known as ATL-962) was approved in September 2013 by the Japanese Ministry of Health, Labor and Welfare for the treatment of obesity, limited to patients with both type 2 diabetes mellitus (T2DM) and dyslipidemia, and with a body mass index (BMI)25 kg/m2 in spite of dietary treatment and/or exercise therapy. As with orlistat, cetilistat works via inhibition of pancreatic lipases in the gut to inhibit fat absorption and thereby reduce caloric uptake from diet. The medicinal chemistry program has not been described in the scientific literature, but the patent describing cetilistat also describes the synthesis of analogs with varied aryl substituents and lipophilic tails. The synthesis of cetilistat involves condensation of a hexadecylcarbonochloridate with 2-amino-5-methylbenzoic acid; other analogs were synthesized by varying the carbonochloridate and 2-aminobenzoic acid components. Cetilistat is a potent inhibitor of human and rat pancreatic lipase with IC50s of 15 and 136 nM, respectively, with little inhibition of trypsin or chymotrypsin.
Chemical Properties Off-white Cryst
Originator Alizyme PLC (United Kingdom)
Uses A novel pancreatic lipase inhibitor for the treatment of obesity in both diabetic and non-diabetic patients.
Brand name Oblean
 
Cetilistat Preparation Products And Raw materials

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