China (Mainland)
2-Methoxyethoxymethyl chloride CAS NO.3970-21-6
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Product Details
Keywords
- API
- Pharmaceutical Intermediate
- Roxithromycin
Quick Details
- ProName: 2-Methoxyethoxymethyl chloride
- CasNo: 3970-21-6
- Molecular Formula: C4H9ClO2
- Appearance: Clear colorless to yellow liquid
- Application: API
- DeliveryTime: within 3-7 day
- PackAge: As required
- Port: Shanghai or Other
- ProductionCapacity: 5 Metric Ton/Month
- Purity: 99%
- Storage: Store in dry, dark and ventilated plac...
- Transportation: by sea or by air
- LimitNum: 1 Kilogram
Superiority
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Details
| 2-Methoxyethoxymethyl chloride Basic information |
| Product Name: | 2-Methoxyethoxymethyl chloride |
| Synonyms: | 1-Chloromethoxy-2-methoxyethane Ethylene Glycol Chloromethyl Methyl Ether MEM-Chloride;2,5-Dioxahexyl chloride, tech;MEM chloride, 1-(Chloromethoxy)-2-methoxyethane, 2-Methoxyethoxymethyl chloride;MethoxyethoxyMethylchlorid;1-(chloromethoxy)-2-methoxy-ethan;1-Chloro-2,5-dioxahexane;BETA-METHOXYETHOXYMETHYL CHLORIDE;ETHYLENE GLYCOL CHLOROMETHYL METHYL ETHER |
| CAS: | 3970-21-6 |
| MF: | C4H9ClO2 |
| MW: | 124.57 |
| EINECS: | 223-589-8 |
| Product Categories: | -;Protection & Derivatization Reagents (for Synthesis);Synthetic Organic Chemistry |
| Mol File: | 3970-21-6.mol |
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| 2-Methoxyethoxymethyl chloride Chemical Properties |
| Melting point | 200-202 °C |
| Boiling point | 50-52 °C13 mm Hg(lit.) |
| density | 1.091 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Fp | >230 °F |
| storage temp. | −20°C |
| form | Liquid |
| Specific Gravity | 1.091 |
| color | Clear colorless to yellow |
| Water Solubility | It hydrolyzes with water. |
| Sensitive | Moisture Sensitive |
| BRN | 1900576 |
| InChIKey | BIAAQBNMRITRDV-UHFFFAOYSA-N |
| CAS DataBase Reference | 3970-21-6(CAS DataBase Reference) |
| NIST Chemistry Reference | «BETA»-methoxyethoxymethyl chloride(3970-21-6) |
| EPA Substance Registry System | Ethane, 1-(chloromethoxy)-2-methoxy- (3970-21-6) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 45-10-36/37/38-20/21/22-46-40-23/24/25-20/22 |
| Safety Statements | 53-26-36/37/39-45-16-23 |
| RIDADR | UN 2810 6.1/PG 2 |
| WGK Germany | 3 |
| F | 10-21 |
| Hazard Note | Toxic |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29091990 |
| 2-Methoxyethoxymethyl chloride Usage And Synthesis |
| Chemical Properties | CLEAR COLOURLESS LIQUID |
| Uses | 2-Methoxyethoxymethyl Chloride is an OH-protecting reagent. 2-Methoxyethoxymethyl Chloride is used in the modification of antibiotics. |
| Purification Methods | Possible impurities are methoxyethanol (b 124o/atm), HCHO and HCl which can be removed below the boiling point of MEMCl. Purify MEMCl by fractional distillation in a vacuum. If too impure, prepare it from methoxyethanol (152g) and s-trioxane (66g) by bubbling a stream of dry HCl (with stirring) until a clear mixture is obtained. Dilute with pentane (900mL), dry (3hours over 100g MgSO4, at 5o), evaporate and the residue is distilled in a vacuum. It is MOISTURE SENSITIVE and TOXIC. The MEM.NEt3+Cl-salt, prepared by reaction with 1.3 equivalents of Et3N (16hours/25o) and dried in a vacuum, has m 58-61o, and is moisture sensitive. [Corey et al. Tetrahedron Lett 809 1976, Yoshimatsu et al. J Org Chem 59 1011 1994, Greene & Wuts Protective Groups in Organic Synthesis edn, J Wiley & Sons NY 1991.] Carcinogen. |
