China (Mainland)
Guanidine hydrochloride CAS NO.50-01-1
- Min.Order: 1 Metric Ton
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Product Details
Keywords
- Guanidine hydrochloride
- 50-01-1
- CH6ClN3
Quick Details
- ProName: Guanidine hydrochloride
- CasNo: 50-01-1
- Molecular Formula: CH6ClN3
- Appearance: powder
- Application: CH6ClN3
- DeliveryTime: 2-3day
- PackAge: 25KG/Cardboard bucket or as required
- Port: shanghai or other
- ProductionCapacity: 5 Metric Ton/Month
- Purity: 98（%）
- Storage: Store in dry, dark and ventilated plac...
- Transportation: by air or by sea
- LimitNum: 1 Metric Ton
Superiority
| Guanidine hydrochloride Basic information |
| Product Name: | Guanidine hydrochloride |
| Synonyms: | guanidine,monohydrochloride;guanidinechloride;Guanidinemonohydrochloride;guanidiniumhydrochloride;AMINOFORMAMIDINE HCL;AMINOFORMAMIDINE HYDROCHLORIDE;AMINOMETHANAMIDINE HCL;AMINOMETHANAMIDINE HYDROCHLORIDE |
| CAS: | 50-01-1 |
| MF: | CH6ClN3 |
| MW: | 95.53 |
| EINECS: | 200-002-3 |
| Product Categories: | proteinmod;Inhibitors;-;Pharmaceutical Intermediates;Miscellaneous Biochemicals |
| Mol File: | 50-01-1.mol |
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| Guanidine hydrochloride Chemical Properties |
| Melting point | 180-185 °C(lit.) |
| density | 1.18 g/mL at 25 °C(lit.) |
| refractive index |
n |
| storage temp. | Store at RT. |
| solubility | H2O: 6 M, clear, colorless |
| form | Crystals |
| color | White to slightly yellow |
| PH | 4.5-5.5 (100g/l, H2O, 20℃) |
| Water Solubility | 2280 g/L (20 ºC) |
| Sensitive | Hygroscopic |
| λmax |
λ: 260 nm Amax: 0.040 λ: 280 nm Amax: 0.025 |
| Merck | 14,4562 |
| BRN | 3591990 |
| Stability: | Stable. Hygroscopic. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 50-01-1(CAS DataBase Reference) |
| EPA Substance Registry System | Guanidine, monohydrochloride(50-01-1) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/38 |
| Safety Statements | 26-36-22 |
| WGK Germany | 1 |
| RTECS | MF4300000 |
| F | 3-10 |
| TSCA | Yes |
| HS Code | 29252000 |
| Toxicity | LD50 orally in Rabbit: 655.3 - 907.1 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
| Guanidine hydrochloride Usage And Synthesis |
| description |
Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant.It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC. Guanidine Hydrochloride is the hydrochloride salt form of guanidine, a strong basic compound with parasympathomimetic activity. Guanidine hydrochloride enhances the release of acetylcholine following a nerve impulse and potentiates acetylcholine actions on muscarinic and nicotinic receptors. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes. Guanidine Hydrochloride is a powerful, chaotropic agent which is widely used for purification of proteins and nucleic acids. Guanidine Hydrochloride is useful for denaturation and refolding of proteins as well as in the recovery of periplasmic proteins and isolation of RNA. At higher concentrations, this strong denaturant has been reported to solubilize denatured insoluble proteins such as inclusion bodies. When utilized at lower concentrations, Guanidine Hydrochloride is noted to be useful in prompting the refolding of denatured proteins. Guanidine Hydrochloride is also been reported to allow return of enzymatic activity in protocols using Guanidine Hydrochloride as a first step. Guanidine Hydrochloride is an inhibitor of RNase. Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized in the synthesis of 2-amino-pyrimidine, 2-amino-6-methyl-pyrimidine and 2-amino-4,6-dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase. |
| Protein Denaturation |
Guanidine Hydrochloride (GdnHCl) is a better denaturant than urea.It should normally give higher and lower values for m and for Cm, respectively, but identical deltaG° values. Since m values in both denaturants can be predicted/estimated from the size of the protein (Myers et al., 1995) and delatG° should not change, yes it is possible-in principle-to predict Cm in one denaturant, knowing its value in the other. but to have a general correlation co-efficient is almost impossible as every protein has unique folding. Though such co-relation may be found for a special protein fold, but what purpose it may serve apart from giving a tentative idea that GdnHCl or urea may be a better denaturant! If you are looking for even better denaturant than Gdn HCl then use GdnSCN, it is better and more effective. |
| Uses |
Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase. Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. |
| Drug intermediates |
Guanidine hydrochloride drug used primarily as an intermediate in the manufacture of sulfadiazine, an important raw material sulfamethyldiazine, sulfamethazine and folic acid. Guanidine hydrochloride (or guanidine nitrate) and ethyl cyanoacetate reaction, cyclization of 2,4-diamino-6-hydroxy pyrimidine, folic acid for the synthesis of antianemic. Furthermore guanidine hydrochloride also used synthetic anti-static agent. |
| Preparation | In Dicyanodiamide and ammonium (Ammonium chloride) as raw material, melt reaction at 170-230 ℃, guanidine hydrochloride obtained crude, refined products. |
| Reference quality standards |
Name of Project Specifications Pharmaceutical grade industrial grade Appearance white crystal; white crystal Content > 99% 99.5% Ammonium <0.3% 0.5% Water Insoluble substance <0.1% 0.1% Moisture <0.3% 0.3% Ash <0.05% 0.05% Water-soluble test qualified; qualified Melting range °C 184-188; 182-188 Absorbance (UV wavelength 260NM) <=0.04 Absorbance (UV wavelength 280NM) <=0.02 PH value (4% aqueous solution) 6.4 ± 0.2 6.4 ± 0.2 |
| References |
# # # # |
| Chemical Properties | White cryst. powder |
| Uses | cholinergic |
| Uses | Guanidine has a good bacterial and fungicidal efficacy when used in low concentration and can also be used as disinfectant. |
| Uses | Used to synthesis medicine, pesticide, dye and other organic compound, is the important material to make sulfanilamide medicine and folacin, and can be used as anti-static agent of compound fibre. |
| Definition | ChEBI: An aminocarboxamidine, the parent compound of the guanidines. |
| Hazard | Toxic by ingestion, evolves hydrogen chloride fumes on heating. |
| Purification Methods | Crystallise the hydrochloride from hot methanol by chilling to about -10o, with vigorous stirring. The fine crystals are filtered through fritted glass, washed with cold (-10o) methanol, dried at 50o under vacuum for 5hours. (The product is purer than that obtained by crystallisation at room temperature from methanol by adding large amounts of diethyl ether.) [Kolthoff et al. J Am Chem Soc 79 5102 1957, Beilstein 3 H 86, 3 II 71, 3 III 160, 3 IV 150.] |
| Guanidine hydrochloride Preparation Products And Raw materials |
Details
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