China (Mainland)
- Product Details
Keywords
- Phenylbutazone
- 50-33-9
- Anti-inflammatory drugs
Quick Details
- ProName: Phenylbutazone
- CasNo: 50-33-9
- Molecular Formula: C19H20N2O2
- Appearance: Off-Whtie Solid
- Application: Medicine
- DeliveryTime: 2-3day
- PackAge: 25KG/Cardboard bucket or as required
- Port: shanghai or other
- ProductionCapacity: 5 Metric Ton/Month
- Purity: 99（%）
- Storage: Dry Storage
- Transportation: by sea or by air
- LimitNum: 1 Kilogram
Superiority
Changzhou Xuanming Chemical Co., Ltd. is dedicated to the technology development, manufacturing, import and export chemicals, which are specialized in pharmaceutical intermediates, pesticide intermediate, industry of fine chemicals and custom synthesis. Now, we enjoy good reputation among customers and take favorable market share in domestic and at abroad.
Changzhou Xuanming Chemical CO., LTD is located in Northern Jiangshu Industry Park, we have modern manufacture bases and some laboratories, which can supply the key intermediate for your projects, and short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard. We have been abided by “treat technology as first, quality as basis, customers as God, and be honest and sincere”. It is our final aim to provide environmental and high technological products and meet customers’ requirements according to keep effors on developing new chemical fields.
Changzhou Xuanming Chemical CO., LTD promises to help you with heart and soul.
Details
| Phenylbutazone Basic information |
| Product Name: | Phenylbutazone |
| Synonyms: | Benzone;Betazed;bizolin;Bizolin 200;bizolin200;Bunetzone;Busone;Buta phen |
| CAS: | 50-33-9 |
| MF: | C19H20N2O2 |
| MW: | 308.37 |
| EINECS: | 200-029-0 |
| Product Categories: | -;Heterocycles;Inhibitors;API;AZOLID;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 50-33-9.mol |
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| Phenylbutazone Chemical Properties |
| Melting point | 104-107 °C |
| Boiling point | 448.76°C (rough estimate) |
| density | 1.1591 (rough estimate) |
| refractive index | 1.6140 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Practically insoluble in water, sparingly soluble in alcohol. It dissolves in alkaline solutions. |
| form | Powder |
| pka | 4.5(at 25℃) |
| color | White to almost white |
| Water Solubility | <0.1 g/100 mL at 23.5 ºC |
| Merck | 14,7277 |
| BRN | 290080 |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. |
| InChIKey | VYMDGNCVAMGZFE-UHFFFAOYSA-N |
| CAS DataBase Reference | 50-33-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenylbutazone(50-33-9) |
| EPA Substance Registry System | 3,5-Pyrazolidinedione, 4-butyl-1,2-diphenyl-(50-33-9) |
| Safety Information |
| Hazard Codes | Xn,T,F |
| Risk Statements | 36/37/38-20/21/22-42/43-45-36-11 |
| Safety Statements | 36/37/39-26-45-22-53-36/37-16 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | UQ8225000 |
| TSCA | Yes |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29331990 |
| Hazardous Substances Data | 50-33-9(Hazardous Substances Data) |
| Phenylbutazone Usage And Synthesis |
| Abstract |
Phenylbutazone, often referred to as "bute,"is a nonsteroidal anti-inflammatory, antipyretic, and analgesic drug (NSAID) for the short-term treatment of pain and fever results from rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, and osteoarthritis. Phenylbutazone has been removed from the United States market due to the availability of newer drugs with less adverse effects. Phenylbutazone is a nonsteroidal anti-inflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body. As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, including injury, menstrual cramps, arthritis and other musculoskeletal conditions. |
| Chemical Property | It is soluble in acetone, chloroform or benzene freely; soluble in ethanol or ether; hardly soluble in water; soluble in sodium hydroxide solution. |
| Mechanism of action | Recent studies have found that the generating mechanism from phenylbutazone anti-inflammatory, analgesic and anti-rheumatic effect is not due to pituitary-adrenal excitement may be due to drugs that inhibit the generation of inflammatory tissue inflammation related active substances, such as synthesis of prostaglandins, white blood cells activities and transfer, release and activity of lysosomal enzymes; pain may also inhibit prostaglandin synthesis results. |
| Pharmacokinetic Study | Oral absorption effect is quickly and completely, reached the peak plasma concentration after about 2 hours. Plasma protein binding rate is 98%. The apparent volume of distribution is 0.12L/kg, such as increasing the dose, volume of distribution has also increased, but the blood concentration does not increase. Therefore, when using repeatedly, the steady-state plasma concentration does not increase linearly. The half-life is 56 to 86 hours. It can cross the placenta into the milk. This product is metabolized by the liver, metabolites is hydroxy phenylbutazone and γ-hydroxy phenylbutazone, still active, The final metabolites are excreted in urine and a small amount of bile is excreted through the urine. |
| Attention and Taboo | The side effects of phenylbutazone incidence rate is about 10%~20%, gastrointestinal irritation can cause nausea, vomiting, abdominal pain, constipation, overdose can cause peptic ulcer, blood in the stool. Damages also occur in other systems, such as rash, dizziness, hematuria, hepatitis, etc. Inhibit the bone marrow caused by neutropenia, or even aplastic anemia, such as the timely withdrawal is more recoverable and therefore should be ground check blood, no effect by 1 week, should not be reused. And double coumarin anticoagulants, sulfonamides, tolbutamide hypoglycemic drugs, increase the plasma concentration, toxicity increases. Sodium, chlorine retention effect, hypertension, edema, heart failure patients cannot use it and limit salt intake during the treatment. Patients with weak liver, osteoporosis, and kidney as well as drug allergy history are contraindicated or appropriate caution. |
| Preparation | Cyclization reaction of hydrogenated azobenzene and diethylmalonic acid diethyl: hydrazobenzene, butyl diethyl malonate, sodium sulfite and methanol are heated with severe reflux 1.5h, born in Bute salt, acidified with acetic acid to give Bute. |
| Acute toxicity |
oral-rat LD50: 245 mg/kg; Oral-Mouse LD50: 270 mg/kg Irritation Data: Eye – rabbit, 100 mg, moderate |
| Flammability hazard properties | thermal decomposition emitted poisonous nitrogen oxides fumes |
| Storage characteristics | Treasury ventilation low-temperature drying; and food raw materials stored separately |
| Extinguishing agent | Water, carbon dioxide, dry powder, foam |
| References |
# # # |
| Chemical Properties | Off-Whtie Solid |
| Uses | For the treatment of backache and ankylosing spondylitis |
| Uses | An inhibitor of Cox. |
| Uses | Phenylbutazone, a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of COX. Phenylbutazone-dependent inactivation of COX and prostacyclin synthase is markedly increased in the presence of 100 μM hydrogen peroxide with half-maximal effects at Phenylbutazone concentrations of 100 and 25 μM for COX and prostacyclin synthase, respectively. |
| Uses | A non-steroidal anti-inflammatory compound. An inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase |
| Brand name | Azolid (Sanofi Aventis); Butazolidin (Novartis);Algesin;Algirreudin;Algoverine;Alka butazolidin;Alkabutazone;Alka-phenylbutazone;Alka-sterazolidin;Anarthral;Apophenylbutazone;Apo-phenylbutazone;Arteopan;Arthirikin;Artibrin;Artrisin;Artrodesmol extra;Bizolin 20;Bizolin 700;Butacal;Butacol;Butadilat;Butadin;Butadyne;Butafenil;Butagros;Butakvertin;Butaparin;Butaphen;Buta-phen;Butarex;Butartiril;Butatril;Butazolidin alka;Butazolidina;Butial;Butinol;Butiwas;Buto beta;Butoroid cream;Butrex;Carudol;Celestalgon;Celestazone;Colfezone;Corbuvit;Dartranol;Debutazon;Delta-butazolidin;Delta-demoplas;Delta-myogit;Delta-tomanol;Deltawaukobuzon;Dephimixn;Dexa tomanol;Dexa-attritin;Dexa-escopyrin;Dexamed;Dexatrzona;Dibuzon;Direstop;Ditrone;Doctofril;Dolosin dexa;Dolpirina;Ectobutazone;Ethibute;Exraheudon;Exrheudon;F 650;Fenibutina;Flebosil;Glycyl;Hepabuzon;Inflazone;Intrabuzone;Mammyl;Megazone;Mepha-butazone;Mepropyrin;Mi 540;Naupax;Neuro-demoplas;Neuzoline m;Novobutazone;Oluprin;Oppazoen;Osadrinim;Parazolidin;Parzolidon;Pasirheuman;Penetradol;Phenbuff;Phenbutazone;Phenylarthrite;Phenylbetazone;Phenylon plus;Phlebolan;Pirabutil;Pirarreumol-b;Pirarreumol-p;Prebutex;Precirhemin;Prednirheumin;Proxyfezone;Proydynam;Pyrbutal;Ranocor;Reopin;Reumilene;Rheopyrin;Rheosolon;Rheumanoln;Rheumaphen;Rheumycalm;Salzone;Servizolidin;Sigma-elmedal;Sintobutina;Stabilat;Tevocodyn;Tibutazone;Ticinil calcio;Ticinil calico;Trabit;Zolapelin;Zolidinium. |
| World Health Organization (WHO) | Phenylbutazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1949 for the treatment of rheumatic disorders. Its use was subsequently associated with serious and sometimes fatal adverse reactions, notably cases of aplastic anaemia and agranulocytosis. Many national drug regulatory authorities consider that more recently introduced drugs offer a safer alternative for most, if not all, patients requiring anti-inflammatory agents. Phenylbutazone has thus been either withdrawn at the national level or retained with rigorously restricted indications for patients unresponsive to other therapy. These restrictions also apply, in general, to combination products containing phenylbutazone. |
| General Description | Odorless white or off-white crystalline powder. Tasteless at first, but slightly bitter aftertaste. pH (aqueous solution) 8.2. |
| Air & Water Reactions | Phenylbutazone is relatively stable at ambient temperatures. Aqueous decomposition of Phenylbutazone occurs by hydrolysis and oxidation. Insoluble in water. |
| Reactivity Profile | Phenylbutazone is incompatible with strong oxidizers, strong acids and strong bases. . |
| Fire Hazard | Flash point data for Phenylbutazone are not available; however, Phenylbutazone is probably combustible. |
| Safety Profile | Suspected human carcinogen producing leukemia. A human poison by parenteral route. An experimental poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Human systemic effects by ingestion and possibly other routes: fever, blood pressure increase, other unspecified vascular effects, damage to kidney tubules and glomeruli, decreased urine volume, blood in the urine, reduction in the number of whte blood cells, and agranulocytosis. Experimental teratogenic and reproductive effects. Human mutation data reported. An eye irritant. An antiinflammatory agent. When heated to decomposition it emits toxic fumes of NOx |
| Veterinary Drugs and Treatments | One manufacturer lists the following as the indications for phenylbutazone: “For the relief of inflammatory conditions associated with the musculoskeletal system in dogs and horses.” (Package Insert; Butazolidin —Coopers). It has been used primarily for the treatment of lameness in horses and, occasionally, as an analgesic/ antiinflammatory, antipyretic in dogs, cattle, and swine. |
| Purification Methods | Crystallise the dione from EtOH. Its pK2 3 is 4.52 (in H2O), 4.89 (in 50% aqueous EtOH) and 5.25 (80% 2-methoxyethanol). It complexes with Hg2+, Cd2+ and Zn2+. It has UV with max at 239.5nm in MeOH+50% aqueous HClO4 and 264nm in aqueous 0.1N NaOH. [Beilstein 24 III/IV 1123.] |
