China (Mainland)
Propylthiouracil/99% CAS NO.51-52-5
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,MoneyGram,Other
- Product Details
Keywords
- Propylthiouracil
- 51-52-5
- Propylthiouracil supplier
Quick Details
- ProName: Propylthiouracil/99%
- CasNo: 51-52-5
- Molecular Formula: C7H10N2OS
- Appearance: white powder
- Application: PharmaIntermediate
- DeliveryTime: 2-3day
- PackAge: 25KG/Cardboard bucket or as required
- Port: shanghai or other
- ProductionCapacity: 5 Metric Ton/Month
- Purity: 99（%）
- Storage: Keep in dry and cool place and away fr...
- Transportation: by sea or by air
- LimitNum: 1 Kilogram
Superiority
| Propylthiouracil Basic information |
| Product Name: | Propylthiouracil |
| Synonyms: | 2,3-dihydro-6-propyl-2-thioxo-4(1h)-pyrimidinon;2,3-dihydro-6-propyl-2-thioxo-4(1h)pyrimidinone;2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone;2-Mercapto-4-hydroxy-6-n-propylpyrimidine;2-Mercapto-6-propyl-4-pyrimidone;4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo-;6-n-Propylthiouracil;6-Propil-tiouracile |
| CAS: | 51-52-5 |
| MF: | C7H10N2OS |
| MW: | 170.23 |
| EINECS: | 200-103-2 |
| Product Categories: | Pyridines, Pyrimidines, Purines and Pteredines;Intermediates & Fine Chemicals;-;Pharmaceuticals;API's;REN-O-SAL;Other APIs;steroids;AZD929 |
| Mol File: | 51-52-5.mol |
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| Propylthiouracil Chemical Properties |
| Melting point | 218-220 °C(lit.) |
| density | 1.1880 (rough estimate) |
| refractive index | 1.5960 (estimate) |
| Fp | 300 °C |
| storage temp. | Refrigerator |
| solubility | 1.1g/l |
| pka | pKa 7.8; 8.3 (Uncertain) |
| form | neat |
| PH | 6-7.5 (5g/l, H2O, 20℃)(slurry) |
| Water Solubility | 1.1 g/L |
| Merck | 14,7869 |
| BRN | 130039 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive. |
| CAS DataBase Reference | 51-52-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Tegretol(51-52-5) |
| EPA Substance Registry System | 4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo- (51-52-5) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-40 |
| Safety Statements | 36/37-45 |
| WGK Germany | 3 |
| RTECS | YR1400000 |
| Hazard Note | Harmful/Irritant |
| HS Code | 29335995 |
| Hazardous Substances Data | 51-52-5(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 1250 mg/kg |
| Propylthiouracil Usage And Synthesis |
| Chemical Properties | White Crystalline Powder |
| Chemical Properties | White crystalline solid or powder. Odorless. Bitter taste. |
| Uses | Antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen |
| Uses | antibacterial |
| Definition | ChEBI: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group. |
| General Description | Odorless white crystalline powder of starch-like appearance. Bitter taste. Saturated solution is neutral or slightly acid to litmus. |
| General Description | Propylthiouracil, 6-propyl-2-thiouracil (Propacil), is a stable, white, crystalline powderwith a bitter taste. It is slightly soluble in water but readilysoluble in alkaline solutions (salt formation). |
| Air & Water Reactions | Sensitive to light. May be sensitive to prolonged exposure to air. Insoluble in water. |
| Reactivity Profile | Propylthiouracil is incompatible with strong oxidizing agents, strong acids and strong bases. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . When reduced will produce hydrogen sulfide. |
| Hazard | Possible carcinogen. |
| Fire Hazard | Flash point data for Propylthiouracil are not available; however Propylthiouracil is probably combustible. |
| Clinical Use | Propylthiouracil is useful in the treatment of hyperthyroidism.There is a delay in appearance of its effects because propylthiouracildoes not interfere with the activity of thyroid hormonesalready formed and stored in the thyroid gland. Thislag period may vary from several days to weeks, dependingon the condition of the patient. The need for three equallyspaced doses during a 24-hour period is often stressed, butevidence now indicates that a single daily dose is as effectiveas multiple daily doses in the treatment of most hyperthyroidpatients. |
| Safety Profile | Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects: agranulocytosis, hepatitis, jaundice. Human teratogenic effects by ingestion: developmental abnormalities of the endocrine system and changes in newborn viability. Human and experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NO,. See also MERCAPTANS. |
| Potential Exposure | Medication (antihyperthyroid; thyroid inhibitor) with human and veterinary applications. |
| Carcinogenicity | Propylthiouracil is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals. |
| Shipping | UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials. |
| Purification Methods | Purify propacil by recrystallisation from H2O (soluble in 900 parts at 20o, and 100 parts at 100o). UV, MeOH: max 277nm. [Anderson et al. J Am Chem Soc 67 2197 1945, Vanderhaegue Bull Soc Chim Belg 59 689 1950, Beilstein 24 III/IV 1333.] |
| Incompatibilities | This chemical is probably combustible; it’s dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanga- nates, perchlorates, chlorine, bromine, fluorine, etc.); con- tact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . Sensitive to light and may be sensitive to air. |
| Waste Disposal | It is inappropriate and possi- bly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding to trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely pack- age the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. |
Details
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