China (Mainland)
Andrographolide CAS NO.5508-58-7
- Min.Order: 1 Metric Ton
- Payment Terms: L/C,D/A,D/P,T/T,MoneyGram,Other
- Product Details
Keywords
- Andrographolide
- 5508-58-7
- C20H30O5
Quick Details
- ProName: Andrographolide
- CasNo: 5508-58-7
- Molecular Formula: C20H30O5
- Appearance: powder
- Application: C20H30O5
- DeliveryTime: 2-3day
- PackAge: 25KG/Cardboard bucket or as required
- Port: shanghai or other
- ProductionCapacity: 5 Metric Ton/Month
- Purity: 99（%）
- Storage: Store in dry, dark and ventilated plac...
- Transportation: by air or by sea
- LimitNum: 1 Metric Ton
Superiority
| Andrographolide Basic information |
| Product Name: | Andrographolide |
| Synonyms: | Andrographolide, 98%, from Andrographis paniculata;hylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-,(1r-(1-alpha(e(s*)),4a-be;3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl]ethylidene]dihydro-4-hydroxyfuran-2(3H)-one;Andrographalide;ANDROGRAPHOLIDE:2(3H)-FURANONE,3-[2-[(1R,4AS,5R,6R,8AS)-DECAHYDRO-6-HYDROXY-5-(HYDROXYMETHYL)-5,8A-DIMETHYL-2-METHYLENE-1-NAPHTHALENYL]ETHYLIDENE]DIHYDRO-4-HYDROXY-, (3E,4S)-,;2(3H)-Furanone, 3-2-(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenylethylidenedihydro-4-hydroxy-, (3E,4S)-;ANDROGRAPHOLIDE(P);3-[2-[Decahydro-6-hydroyx-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenylethylidene]dihydro-4-hydroxy-2(3H)-furanone |
| CAS: | 5508-58-7 |
| MF: | C20H30O5 |
| MW: | 350.45 |
| EINECS: | 226-852-5 |
| Product Categories: | Di-Terpenoids;Asymmetric Synthesis;Chiral Building Blocks;Complex Molecules;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;plant extract-;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Herb extract;chemical reagent;natural product;-;pharmaceutical intermediate;phytochemical |
| Mol File: | 5508-58-7.mol |
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| Andrographolide Chemical Properties |
| Melting point | 229-232 °C(lit.) |
| alpha | -126 º (c=1.5,HAc) |
| density | d421 1.2317 |
| storage temp. | +2C to +8C |
| form | Off-white solid |
| optical activity | [α]20/D 126°, c = 1.5 in acetic acid |
| λmax | 223nm(MeOH)(lit.) |
| Merck | 14,633 |
| BRN | 42762 |
| InChIKey | BOJKULTULYSRAS-QPSYGYIJSA-N |
| CAS DataBase Reference | 5508-58-7 |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | LU3490750 |
| HS Code | 29322980 |
| Andrographolide Usage And Synthesis |
| Description |
Andrographolide is the bitter principle, a colorless and neutral crystalline substance. It is the major labdane diterpenoid isolated from Andrographis paniculate. It exhibits antiviral, anti-inflammatory, and anticancer activities. The underlying mechanism is the inhibition of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling (specifically p38 MAPK/ERK1/2) pathway and downstream transcription factors such as nuclear factor kappa B (NF-κB) and nuclear factor of activated T cells (NFAT). Andrographolide is also confirmed with chemopreventive effects against and the inhibitory effects on cancer cell growth in breast, colon, epidermoid, gastric, liver, leukemia, myeloma, peripheral blood lymphocytes, and prostate cancers. Andrographolide has been used for liver complaints and fever, and as an anti-inflammatory and immunostimulant. Andrographolide exerts anti-growth and pro-apoptotic effects on human rheumatoid arthritis fibroblast- like synoviocytes, the main cellular constituent of pannus, that combined with a massive infiltration of lymphocytes and macrophages, invades and destroys the local articular structure. Thereby, andrographolide is proposed to be used in Rheumatoid Arthritis and other autoimmune diseases. |
| References |
[1] Mari a A. Hidalgo, Juan L. Hancke, Juan C. Bertoglio and Rafael A. Burgos (2013) Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease in book “Innovative Rheumatology” [2] # [3] Mitchell Low, Cheang S Khoo, Gerald Münch, Suresh Govindaraghavan, Nikolaus J Sucher (2014) An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide, BMC Complementary and Alternative Medicine, 15:18 |
| Chemical Properties | colorless Plates |
| Uses | Andrographolide is a labdane diterpenoid. Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata. Andrographolide showed significant antihepatotoxic action in P. berghei K173- induced hepatic damage in M. natalensis. Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases. These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent. |
| Uses | antineoplastic |
| Definition | ChEBI: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties. |
| Anticancer Research | It is a labdane diterpenoid, which shows cytotoxic effect against different cancercell lines like human epidermoid cancer cells (KB), lymphocytic leukemia cells(P388), breast cancer cells (MCF-7), and colon cancer cells (HCT-116). It inhibitsthe proliferation of colon cancer cells (HT-29) and exerts pro-differentiative effecton mouse myeloid leukemia M1 cell line (Desai et al. 2008). |
| Andrographolide Preparation Products And Raw materials |
| Raw materials | Etanol |
Details
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