China (Mainland)
Acotiamide hydrochloride trihydrate CAS NO.773092-05-0
- Min.Order: 10 Gram
- Payment Terms: L/C,D/A,D/P,T/T,MoneyGram,Other
- Product Details
Keywords
- Acotiamide hydrochloride trihydrate
- 773092-05-0
- C21H31ClN4O5S
Quick Details
- ProName: Acotiamide hydrochloride trihydrate
- CasNo: 773092-05-0
- Molecular Formula: C21H31ClN4O5S
- Appearance: white to off-white powder
- Application: acotiamide hydrochloride
- DeliveryTime: within 3-7 day
- PackAge: As required
- Port: shanghai or other
- ProductionCapacity: 300 Kilogram/Month
- Purity: 99（%）
- Storage: Preserved closely at room tempreture
- Transportation: by sea or by air
- LimitNum: 10 Gram
Superiority
Changzhou Xuanming Chemical Co., Ltd. is dedicated to the technology development, manufacturing, import and export chemicals, which are specialized in pharmaceutical intermediates, pesticide intermediate, industry of fine chemicals and custom synthesis. Now, we enjoy good reputation among customers and take favorable market share in domestic and at abroad.
Changzhou Xuanming Chemical CO., LTD is located in Northern Jiangshu Industry Park, we have modern manufacture bases and some laboratories, which can supply the key intermediate for your projects, and short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard. We have been abided by “treat technology as first, quality as basis, customers as God, and be honest and sincere”. It is our final aim to provide environmental and high technological products and meet customers’ requirements according to keep effors on developing new chemical fields.
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Details
| Acotiamide hydrochloride trihydrate Basic information |
| Product Name: | Acotiamide hydrochloride trihydrate |
| Synonyms: | Acotiae;4-Thiazolecarboxamide, N-[2-[bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-,hydrochloride,hydrate(1:1:3);Acofide trihydrate;N-{2-[bis(1-methylethyl)amino]ethyl}-2-[(2-hydroxy-4,5-dimethoxyphenylcarbonyl)amino];Acotiamide HCl Hydrate;N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide monohydrochloride trihydrate;Acotiamide HCl Trihydrate;N-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydro |
| CAS: | 773092-05-0 |
| MF: | C21H31ClN4O5S |
| MW: | 487.013 |
| EINECS: | 1592732-453-0 |
| Product Categories: | Inhibitors;API;- |
| Mol File: | 773092-05-0.mol |
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| Acotiamide hydrochloride trihydrate Chemical Properties |
| Safety Information |
| Acotiamide hydrochloride trihydrate Usage And Synthesis |
| Description | In June 2013, the Ministry of Health, Labor and Welfare in Japan approved acotiamide (also referred to as Z-338 and YM443), for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia (FD). Acotiamide enhances acetylcholine release from enteric neurons through selective muscarinic acetylcholine receptor M1, M2 antagonism, and inhibition of AChE, thereby enhancing gastric emptying and gastric accommodation. Acotiamide inhibits the acetylcholine-induced Ca2+-activated Cl-current with an IC50 of 1.8 μM in oocytes expressing muscarinic M1 receptors and in oocytes expressing muscarinic M2 receptors, acotiamide inhibited the acetylcholine-induced K+ currents with an IC50 of 10.1 μM. However, studies in conscious dogs, guinea-pig gastric muscle strips and assays with human cholinesterase indicate that acotiamide inhibits AChE with a Ki of 610 nM suggesting that acotiamide stimulates gastric motility mainly by inhibiting AChE activation. In a restraint stress-induced rat model, acotiamide significantly improved delayed gastric emptying and feeding inhibition but did not affect normal gastric emptying or feeding in intact rats. A synthetic route to acotiamide that employs pyridine hydrochloride to selectively cleave a 2-substituted methyl ether from a 2,4,5-trimethoxy benzamide intermediate, as a key step, has been reported. |
| Originator | Zeria Pharmaceutical (Japan) |
| Brand name | Acofide |
