China (Mainland)
- Product Details
Keywords
- Crizotinib
- 877399-52-5
- C21H22Cl2FN5O
Quick Details
- ProName: Crizotinib
- CasNo: 877399-52-5
- Molecular Formula: C21H22Cl2FN5O
- Appearance: White crystal
- Application: API intermediate
- DeliveryTime: 2-3day
- PackAge: 25KG/Cardboard bucket or as required
- Port: shanghai or other
- ProductionCapacity: 5 Metric Ton/Month
- Purity: 99（%）
- Storage: Shady, sealed, dry place
- Transportation: by sea or by air
- LimitNum: 1 Kilogram
Superiority
| crizotinib basic information | |
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| side effects |
crizotinib (xalkori) is an oral receptor tyrosine kinase inhibitor indicated for the treatment of patients with advanced or metastatic non-small cell lung cancer (nsclc). common side effects with xalkori use include upper respiratory infection, nausea, vomiting, stomach pain, decreased appetite, insomnia, dizziness, tired feeling, diarrhea, constipation, rash or itching, cold symptoms (stuffy nose, sneezing, sore throat), numbness or tingling, or swelling in your hands or feet. # |
| fda approves crizotinib capsules |
on march 11, 2016, the u. s. food and drug administration approved crizotinib capsules (xalkori, pfizer, inc.) for the treatment of patients with metastatic non-small cell lung cancer (nsclc) whose tumors are ros1-positive. crizotinib was first approved in 2011 for the treatment of patients whose tumors are anaplastic lymphoma kinase (alk)-positive. the current approval was based on a multicenter, single-arm trial in patients with metastatic ros1 rearrangement-positive nsclc. all patients received crizotinib 250 mg orally twice daily. the efficacy outcome measures were objective response rate (orr) according to recist v1.0 as evaluated by an independent radiology review (irr) and as evaluated by the investigators. duration of response (dor) was an additional outcome measure. the trial enrolled 50 patients with an age range of 25-77 years whose tumors were prospectively determined to be ros1-positive by fluorescence in situ hybridization (fish; 96%) or reverse transcription polymerase chain reaction (rt-pcr; 4%) clinical trial assays. the orr by irr was 66% (95% ci: 51%, 79%) with a median dor of 18 months. the orr according to investigators was 72% (95% ci: 58%, 84%). the safety results of this trial were generally consistent with the safety profile of crizotinib evaluated in 1,669 patients with alk-positive metastatic nsclc. the most common adverse reactions of xalkori are vision disorders, nausea, diarrhea, vomiting, edema, constipation, elevated transaminases, fatigue, decreased appetite, upper respiratory infection, dizziness, and neuropathy. the recommended dose and schedule for crizotinib is 250 mg capsules taken by mouth twice daily. # |
| chemical properties | white solid |
| uses | a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-met) kinase and anaplastic lymphoma kinase (alk). a potential antitumor agent. |
| uses | crizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-met) kinase and anaplastic lymphoma kinase (alk). crizotinib is a potential antitumor agent. |
| uses | pf-2341066 (crizotinib) is a potent inhibitor of c-met and alk with ic50 of 11 nm and 24 nm, respectivley |
Details
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